Ozone Therapy, Medical Ozone, Ozone Medicine, Free Radicals, Healing, Oxidation, AIDS, Cancer, Angiogensis. Ozone Home and Medical Uses (III): Ozone Treatment for Viruses, Cancer, Aids, Lyme, Gangrene et al. Is healing induced via a mild oxidative stress? Abstract. The potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological components. The line between effectiveness and toxicity of ozone may be dependent on the strength of the oxidative stress. Medical Ozone Products. Welcome to the product page! These products have been tested and are known to work well in conjunction with oxygen therapies, there are also links to training, books, videos and other merchandise that. O3MedicalOzone.com - the portal for everything about Medical Grade Ozone, ozone protocols, ozone therapy, treatments, ozone clinics, articles, resources, medical grade ozone generators, peer reviewed studies, books, ozone. As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not. Severe oxidative stress activates nuclear transcriptional factor kappa B (NF. However, moderate oxidative stress activates another nuclear transcriptional factor, nuclear factor- erythroid 2- related factor 2 (Nrf. Nrf. 2 then induces the transcription of antioxidant response elements (ARE). Transcription of ARE results in the production of numerous antioxidant enzymes, such as SOD, GPx, glutathione- s- transferase(GSTr), catalase (CAT), heme- oxygenase- 1 (HO- 1), NADPH- quinone- oxidoreductase (NQO- 1), phase II enzymes of drug metabolism and heat shock proteins (HSP). Both free antioxidants and anti- oxidative enzymes not only protect cells from oxidation and inflammation but they may be able to reverse the chronic oxidative stress. Based on these observations, ozone therapy may also activate Nrf. NF. Furthermore, activation of Nrf. Alzheimer's and Parkinson's diseases. Mild immune responses are induced via other nuclear transcriptional factors, such as nuclear factor of activated T- cells (NFAT) and activated protein- 1 (AP- 1). Additionally, the effectiveness of ozone therapy in vascular diseases may also be explained by the activation of another nuclear transcriptional factor, hypoxia inducible factor- 1. Oxygen OXYGEN, OZONE, & HYDROGEN PEROXIDE Majid Ali, M.D. Free online database of nutritional supplement information to help you particapate actively in your own wellness. Directory of nutritional supplement products, browse by medical conditions or by company, purchase nutritional. Ozone-infused oil pulling: A revolution in oral health combining modern technology with ancient medicine. Tuesday, September 16, 2014 by Mike Adams, the Health Ranger Tags: oil pulling, ozone therapy, oral health. Chow practices in Vancouver, BC, Canada, and has used Ozone in her practice for many years.) Healthy cells need oxygen. Most infections occur because of the invasion of anaerobes that. Recently these concepts have become widely accepted. The versatility of ozone in treating vascular and degenerative diseases as well as skin lesions, hernial disc and primary root carious lesions in children is emphasized. Further researches able to elucidate whether the mechanisms of action of ozone therapy involve nuclear transcription factors, such as Nrf. NFAT, AP- 1, and HIF- 1. The first report on ozone therapy was published by Wolff in 1. Breakthrough in human cell transformation could revolutionize regenerative medicine Date: January 19, 2016 Source: University of Bristol Summary: A breakthrough in the transformation of human cells by an international team of. Medical Ozone and Cancer Medical Ozone Saves Lives in Europe, but the FDA continues to Prevent Formal Testing in the USA. Although ozone therapy is now used all over the world, it has not yet been accepted as orthodox medicine in all countries. About two decades ago, both nitrogen oxide (NO) and carbon monoxide (CO) were only considered as toxic air pollutants or gases derived from cigarette smoke. However, today, they are regarded to as essential gases, since both NO and CO are responsible for very important physiological actions within the body . Similarly hydrogen sulfide, a toxic gas, is now used as a drug for the treatment of osteoporosis . Additionally, low dose radiation was also reported to have beneficial effects within radiated cells, in particular, by prolonging the lifespan of cells via the hormesis mechanism . Thus, our understanding of toxic compounds and their effects within the body appears to be constantly changing as we have realized that toxicity depends entirely on the dosage. Both exercise and caloric restriction are excellent examples of the hormetic effect . It is well known that moderate exercise is beneficial for health. Furthermore, caloric restriction is also well known to delay disease onset and mortality . Furthermore, cells can quickly induce biological responses against oxidative stress to maintain biological homeostasis and adapt to such stresses. And, some nuclear factors induce various biological responses against oxidative stress. The findings of animal experiments and studies on the clinical applications of ozone therapy are included. Additionally, we explore the possibility that the mechanisms of action of ozone therapy may be via the activation of antioxidant protection systems, where moderate oxidative stress may induce the activation of nuclear transcriptional factors such as nuclear factor- erythroid 2- related factor 2 (Nrf. The ozone paradox: is ozone always toxic? Reaction with ozone and biological components. Pryor et al . Briefly, inhaled ozone reacts with polyunsaturated fatty acids (PUFA), which are found in the lipids of the alveolar lining layer (ALL), to produce ozone- specific products, referred to as lipid ozonation products (LOPs). Ozone can also react with unsaturated fatty acids to produce Criegee ozonide in the absence of H2. O. However, in the presence of H2. O, aldehydes and hydrogen peroxide (H2. O2) are produced . Since H2. O is abundant within the pulmonary system, the main reaction with ozone will be the formation of aldehyde and H2. O2 products. The net reaction is as follows: H2. O2+Fe++- -- -- -. These products may activate specific lipases, such as phospholipase A2 or phospholipase C, to release arachidonic acid (AA). In fact, AA levels increase more than 1. The released AA can then be converted into other chemical mediators, such as various prostaglandins (PGs) and platelet activating factors (PAF), via cyclooxygenases (COXs) and lipoxygenases (LOXs) to induce an inflammatory response. Furthermore, it has been reported that 4- hydroxynonenal (4- HNE), the most toxic type of aldehyde . Effects of ozone on the airways: Airway hyperreactivity and inflammation. Airway hyper reactivity is one of the earlier signs of ozone inhalation. An increase in airway hyperreactivity is accompanied by airway inflammation. These changes are similar to those by cigarette smoking. Briefly, it was demonstrated that cigarette smoke extract (CSE) added into a cell culture system of human tracheal smooth muscle cells binds to Toll- like receptor 4 (TLR4). TLR4 then activates NADPH- oxidase via adaptor molecules, such as My. D8. 8, to produce reactive oxygen species (ROS). Further, ROS activate mitogen activated protein kinases (MAPKs), and MAPK phosphorylates I. COX2 then produces PGE2, which stimulates a number of cytokines, among which TNF. The eicosanoide and cytokines then induce the airway inflammation during the early stage of exposure. These reactions also occur in airway epithelial cells, endothelial cells, and macrophages. This signaling cascade is also supported by the findings of Williams et al. They demonstrated that TRL2 or TLR4 knockout mice do not have airway hyperreactivity and neutrophil infiltration even after an exposure to ozone of 3 ppm. These observations strongly suggest that there is a strong relationship between inflammation and TLR. There are good experimental . The skin, if extensively exposed, may also contribute to the damage . Consequently the strong reactivity of ozone, which has an electrochemical potential value, E. However it will be shown that this dogma is not supported by comparing the action of ozone on the lung surface versus human blood. Obviously it must be said that ozone must be never inhaled by anyone in the clinic. However, it seems that ozone may be produced in our body similar to NO, CO and H2. S: it has been reported that antibody- catalyzed water- oxidation pathway produced an additional molecular species with a chemical signature to that of ozone . This species is also generated during the oxidative burst of activated human neutrophils and during inflammation . It is clear how the respiratory system undergoing a chronic oxidative stress can release slowly, but steadily, a huge amount of already mentioned toxic compounds able to act locally and to enter the circulation and cause serious damage. Origin, distribution and fate of toxic compounds released by the pulmonary system during and after ozone exposure. At the airspace level, the alveolar cells are constantly overlaid by a film composed of water, salts and a myriad of biomolecules such as a profusion of surfactant phospholipids and a very small amounts of proteins, lipophilic and hydrophilic antioxidants. Any inspired gas, depending upon its relative concentration and pressure, must first dissolve into the aqueous layer before reaching the alveolar microcirculation and the erythrocytes. This process implies a physical transport regulated by a pressure gradient and a diffusion process. On the other hand, it is known that ozone, in contact with biological water, does not follow Henry's law and, although it is ten fold more soluble than oxygen, it is not transferred into the alveolar capillaries because it reacts immediately with the biomolecules present in the Alveolar Lining Layer (ALL). It must emphasized that the average thickness of ALL is only 0. As it was hypothesized . As cholesterol is a component of the epitherial lining fluids (ELF) and because its double bond is readily attacked by ozone, it can give rise to biologically active oxysterols . First of all, by considering the expanse of the alveolar surface (1 m. ALL ranges only between 1. L of blood include about 2. L of plasma. Moreover, the erythrocyte mass, amounting to about 2. Erythrocytes, via glucose- 6- phosphate dehydrogenase activity in the pentose cycle, can continuously supply NADPH- reducing equivalents. The amount of plasma albumin acting as a . Moreover erythrocytes have a GSH content of about 2. M (almost 8. 00- fold higher than plasma) and therefore they contain a huge reserve. In the course of evolution, aerobic organisms have developed a sophisticated antioxidant system against oxygen and, although about 2% of the inhaled oxygen generates superoxide anion, this is normally neutralized at an alveolar p. O2 pressure of 1. Hg. It is useful, however, to bear in mind that rats inhaling pure oxygen (alveolar pressure at about 7. Hg) die within 6. In order to understand the effects of a daily 8- hour ozone exposure (April- October), we need to know the average environmental ozone levels that vary considerably for many reasons. The US Clean Air Act has set an ozone level of 0. U. S. Environmental Protection Agency, 2. Evaluation of recent studies . However, ozone concentration in urban air can exceed 0. For 8 h at rest (a tidal volume of about 1.
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